il-1β (+3953 c/t) and il-8 (-251 a/t) gene polymorphisms in h. pylori mediated gastric disorders
Authors
abstract
background: previous studies imply that il-1 and il-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon h. pylori infection. objective: the aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in iranian population. methods: one hundred and forty three unrelated individuals with different gastric disorders and 374 normal individuals with no gastric disorders and with a negative serology test for h. pylori (control group) were studied for the association between il-1β (+3953 c/t) and il-8 (-251 a/t) gene polymorphisms and h. pylorimediated gastritis and gastric ulcer. an analysis of genotype frequency for these genes was performed using rflp-pcr. results: based on the data obtained from culture and pathologic findings, the patients were classified into three subpopulations: h pylori+ non-ulcerative gastritis+, h. pylori+ ulcerative gastritis+ and h. pylori- non-ulcerative gastritis+. a significantly higher frequency of tt genotype (p=0.02) in il-1β +3953 in h. pylori+ ulcerative gastritis+ was revealed compared to the control group. there were no significant differences among other subpopulations. no significant differences in allele and genotype frequencies of il-8 (-251a/t) were found among the patients. conclusion: the data suggest that tt genotype in il-1β +3953 may be a major contributing genetic risk factor for h. pylori induced gastric ulcer. moreover, the role of other bacterial and host response factors, such as bacterial adherence peptides, host chemokines, and genes involved in gastric acid secretion, must be further investigated in different ethnic populations.
similar resources
IL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disorders
Background: Previous studies imply that IL-1 and IL-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon H. pylori infection. Objective: The aim of this study was to determine the potential association between the prevalence of certain polymorphic sites and the risk of gastric disorders in Iranian population. Methods: One hundred and forty ...
full textThe Role of Interleukin 1β Gene Polymorphism in Gastric Cancer in North-eastern Iran
Background and Objective: Host genetic factors such as cytokine gene polymorphisms as well as Helicobacter pylori (H. pylori) infection have been found to be associated with gastric cancer risk . Interleukin 1 is a pro-inflammatory cytokine involved in H. pylori-induced gastric inflammation. Therefore, w...
full textInflammasome and IL-1β-Mediated Disorders
The NLRP3 inflammasome is an intracellular complex that regulates the release of proinflammatory cytokines such as interleukin-1beta in response to exogenous pathogens and endogenous danger signals. Evidence from studies involving human genetics, human ex vivo mononuclear cell responses, and in vivo and in vitro murine models confirms the importance of the inflammasome and interleukin-1beta in ...
full textComparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis
B ACKGROUND: Helicobacter pylori is a noninvasive microorganism causing intense gastric mucosal inlammatory and immune reaction. The gastric mucosal levels of the proinlammatory cytokines Interleukin 6 (IL-6) and IL-8 have been reported to be increased in H. pylori infection, but the serum levels in H. pylori infection is still controversial. The purpose of this study was to investigate the ser...
full textIL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage
Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 A/C, -819 C/T, -1082 A/G), IL-6 (-174 C/G) and IL-17 (-197 G/A) in Iranian women. Method: Po...
full textStudy on the association between IL-1β, IL-8 and IL-10 gene polymorphisms and risk of coronary artery disease.
We aimed to evaluate the role of genetic polymorphisms in IL-1β, IL-8 and IL-10 in the risk of coronary artery disease (CAD). We identified 325 patients with CAD and 342 control subjects without CAD between January 2013 and December 2014. Genotyping of IL-1β +3954 C/T, IL-1β -511 C/T, IL-8-251T/A, IL-10-1082A/G and IL-10-819C/T was performed in a 384-well plate format on the Sequenom MassARRAY ...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of immunologyجلد ۷، شماره ۲، صفحات ۹۶-۱۰۸
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023